What age does the ss disease manifest

Kindly let me know at what age the Sickle Cell Disease begin to manifest in a child?

Mrs Ibukun (by SMS)

Sickle cell disease (SCD) usually manifests early in childhood. For the first 6 months of life, infants are protected largely by elevated levels of the healthy Haemoglobin which they got from the womb. However, the condition becomes evident soon thereafter. The most common clinical manifestation of SCD is vaso-occlusive crisis. A vaso-occlusive crisis occurs when the microcirculation is obstructed by sickled Red Blood Cells causing ischemic injury to the organ supplied and resultant pain. Pain crises constitute the most distinguishing clinical feature of sickle cell disease and are the leading cause of emergency department visits and hospitalisations for affected patients.

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