Eight fire engines and 58 firefighters are at the scene in Mile End district of the city, the London Fire Brigade said.
It said half of a 12th floor flat was in flames.
There was no immediate word on possible injuries or what may have caused the fire.
A devastating inferno killed 72 people at London’s 24-storey Grenfell Tower one year ago.
The blaze spread rapidly along the outside of the tower.
Residents had for several years expressed safety fears about the use of potentially combustible external cladding.
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